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- Evidence of a
Pluripotent
Human
Embryonic Stem
Cell Line
Derived from a
Cloned
Blastocyst: Science, Vol.
303, No. 5664.
(12 March
2004), pp.
1669-1674.Soma
tic cell
nuclear
transfer
(SCNT)
technology has
recently been
used to
generate
animals with a
common genetic
composition.
In this study,
we report the
derivation of
a pluripotent
embryonic stem
(ES) cell line
(SCNT-hES-1)
from a cloned
human
blastocyst.
The SCNT-hES-1
cells
displayed
typical ES
cell
morphology and
cell surface
markers and
were capable
of
differentiatin
g into
embryoid
bodies in
vitro and of
forming
teratomas in
vivo
containing
cell
derivatives
from all three
embryonic germ
layers in
severe
combined
immunodeficien
t mice. After
continuous
proliferation
for more than
70 passages,
SCNT-hES-1
cells
maintained
normal
karyotypes and
were
genetically
identical to
the somatic
nuclear donor
cells.
Although we
cannot
completely
exclude the
possibility
that the cells
had a
parthenogeneti
c origin,
imprinting
analyses
support a SCNT
origin of the
derived human
ES cells.Woo
Hwang, Young
Ryu, Jong
Park, Eul
Park, Eu Lee,
Ja Koo, Hyun
Jeon, Byeong
Lee, Sung
Kang, Sun Kim,
Curie Ahn,
Jung Hwang, Ky
Park, Jose
Cibelli, Shin
Moon
Source: Science, Vol. 303, No. 5664. (12 March 2004), pp. 1669-1674. - Patient-Specif
ic Embryonic
Stem Cells
Derived from
Human SCNT
Blastocysts.: Science (19
May
2005)Patient-s
pecific,
immune-matched
human
embryonic stem
cells (hESC)
are
anticipated to
be of great
biomedical
importance for
studies of
disease and
development,
and to advance
clinical
deliberations
for stem cell
transplantatio
n. Eleven hESC
lines were
established by
nuclear
transfer
(SCNT; NT) of
skin cells
from patients
with disease
or injury into
donated
oocytes. These
lines
(NT-hESCs),
grown on human
feeders from
the same
NT-donor or
genetically-un
related
individuals,
were
established at
high rates,
regardless of
NT-donor sex
or age.
NT-hESCs were
pluripotent,
chromosomally
normal, and
match
NT-patient's
DNA. Major
Histocompatibi
lity Complex
(MHC) identity
of each
NT-hESC with
the patient's
showed
immunological
compatibility,
important for
eventual
transplantatio
n. With the
generation of
these
NT-hESCs,
evaluations of
genetic and
epigenetic
stability can
be made.
Additional
work remains
regarding the
development of
reliable
directed
differentiatio
n and the
elimination of
remaining
animal
components.
Prior to
clinical use
of these
cells,
preclinical
evidence is
required to
prove that
transplantatio
n of
differentiated
-NT-hESCs can
be safe,
effective and
tolerated.Woo
Suk Hwang,
Sung Il Roh,
Byeong Chun
Lee, Sung Keun
Kang, Dae Kee
Kwon, Sue Kim,
Sun Jong Kim,
Sun Woo Park,
Hee Sun Kwon,
Chang Kyu Lee,
Jung Bok Lee,
Jin Mee Kim,
Curie Ahn, Sun
Ha Paek, Sang
Sik Chang,
Jung Jin Koo,
Hyun Soo Yoon,
Jung Hye
Hwang, Youn
Young Hwang,
Ye Soo Park,
Sun Kyung Oh,
Hee Sun Kim,
Jong Hyuk
Park, Shin
Yong Moon,
Gerald
Schatten
Source: Science (19 May 2005) - Nuclear
reprogramming
of cloned
embryos and
its
implications
for
therapeutic
cloning: Nature
Genetics, Vol.
39, No. 3. (26
February
2007), pp.
295-302.Xiangz
hong Yang,
Sadie Smith,
Cindy Tian,
Harris Lewin,
Jean-Paul
Renard,
Teruhiko
Wakayama
Source: Nature Genetics, Vol. 39, No. 3. (26 February 2007), pp. 295-302. - Criminal law
in the
regulation of
somatic cell
nuclear
transfer.: American
Journal of
Bioethics,
Vol. 7, No. 2.
(February
2007), pp.
73-75.AM Viens
Source: American Journal of Bioethics, Vol. 7, No. 2. (February 2007), pp. 73-75.
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